[NAB, CPCN Seminar] Engineering biomaterials and matrix signals to prevent infection, inflammation, and promote repair of large-scale bone defects

Biomaterial strategies to repair craniomaxillofacial (CMF) defects, or large-scale bone defects, require materials which can provide structural support, resist infection, and provide cellular signals to promote bone formation. Mineralized collagen scaffolds are biomaterials capable of regenerating bone in small animal models; however, like many biomaterials, struggle to repair large-scale defects in clinically-relevant models (porcine).