Emily Jacobs earned a BA in Neuroscience at Smith College and a Ph.D. in Neuroscience at the University of California, Berkeley under the mentorship of Mark D’Esposito. Her graduate work was supported by a National Science Foundation Graduate Research Fellowship and an Elizabeth Roboz Einstein Fellowship in Neurosciences and Human Development. Following her Ph.D., she was named a Robert Wood Johnson Foundation Health and Society Scholar at the University of California, San Francisco. Next, she joined the faculty at Harvard Medical School in the Department of Psychiatry, under the mentorship of Jill Goldstein and with the support of a National Institutes of Health “BIRCWH” Career Development Award. She is the recipient of the Stuart T. Hauser Clinical Research Fellowship at Harvard Medical School, the Patricia Goldman-Rakic Fellow for Women in Neuroscience, the American College of Neuropsychopharmacology Early Career Travel Award, and the Organization for the Study of Sex Differences Travel Award.
A rapidly growing body of evidence from rodent and nonhuman primate studies has established estradiol’s influence on synaptic organization within memory circuitry, including the hippocampus and prefrontal cortex. Despite significant implications for human health, few laboratories are examining these relationships at the human cognitive neuroscience level. The goal of my research is to use brain imaging to establish basic principles of how sex steroid hormones shape the neural circuitry underlying higher order cognitive functions. This includes defining the role of sex steroids in the healthy adult brain and, in turn, exploring how the depletion of ovarian hormones during reproductive aging influences memory circuitry. I use a multi-tier approach that includes fMRI, molecular PET imaging, neuroendocrinology and imaging genetics. This research program leverages the conceptual and technical strengths of cognitive neuroscience to fill a gap in basic science, while addressing practical applications to women’s health.
- Jacobs E.G.,Weiss B., Makris N., Whitfield-Gabrieli S., Buka S., Klibanski A., Goldstein J.M. (2016) Reorganization of functional networks in verbal working memory circuitry in early midlife: The impact of sex and menopausal status. Cerebral Cortex doi:10.1093/cercor/bhw127
- Jacobs E.G., Holsen L., Lancaster K., Makris N., Whitfield-Gabrieli S., Remington A., Weiss B., Buka S., Klibanski A., Goldstein J.M. (2015) 17-Estradiol differentially regulates stress circuitry activity in healthy and depressed women. Neuropsychopharmacology. 40, 566-576. PMID: 25113601 PMCID: PMC4289944
- Cohen J., Gallen C., Jacobs E.G., Lee T., D’Esposito M. (2014) Quantifying the reconfiguration of intrinsic networks during working memory. PLoS ONE. 9(9): e106636. PMCID: PMC4156328
- Jacobs E.G., Epel ES, Lin J, Blackburn EH, Rasgon NL. (2014) Relationship between leukocyte telomere length, telomerase activity and hippocampal volume in early aging. JAMA Neurology. 71(7):921-923. PMID: 25023551
- Jacobs E.G., Kroenke C, Lin J, Epel ES, Kenna HA, Blackburn EH, Rasgon NL. (2013) Accelerated cell aging in female APOE-ε4 carriers: Implications for hormone therapy use. PLoS ONE 8(2): e54713. PMCID: PMC3572118 (Faculty of 1000 selection)
- John N., Jacobs E.G., Mendoza-Denton R., Francis D.D. (2012) Wealth, health and the moderating role of implicit social class bias. Annals of Behavioral Medicine 45(2):173-179. PMID: 23229159
- Jacobs E.G., D’Esposito M. (2011) Estrogen shapes dopamine-dependent cognitive function: Implications for women’s health. Journal of Neuroscience. 31(14):5286-5293. PMCID: PMC3089976
- Cools R., Sheridan M., Jacobs E., D'Esposito M. (2007). Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory. Journal of Neuroscience. 27(20):5506–5514 PMID: 1750757
- Wraga M., Helt M., Jacobs E., & Sullivan K. (2007). Neural basis of stereotype-induced shifts in women’s mental rotation performance. Social, Cognitive, and Affective Neuroscience 2(1):12-19 PMCID: PMC2555429
- Wraga M., Duncan L., Jacobs E., Helt M., & Church J. (2006). Stereotype susceptibility narrows the gender gap in imagined self-rotation performance. Psychonomic Bulletin & Review 13(5):813-9 PMID: 17328378