The Janušonis Lab

Department of Psychology
Neuroscience Research Institute
University of California at Santa Barbara

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Platelet Hyperserotonemia of Autism

The current state of the theory of the platelet hyperserotonemia of autism is presented in Janušonis (2008) [Open Access]. This paper supersedes our two previous theoretical papers (Janušonis (2005) Theor. Biol. Med. Model. 2: 27 and Janušonis (2005) Med. Hypotheses 64: 742-750).

The numerical values of the parameters are being constantly updated as more data become available. The table below lists:

Any corrections or comments will be greatly appreciated.

Most recent update: June 5, 2008.

PARAMETER UNITS ORIGINAL VALUE UPDATED VALUE SOURCE OF UPDATE OTHER SOURCES
5-HT MW g mol-1 176
D m2 min-1 6.00 ∙ 10-8
db m3 min-1 6.00
dg min-1 5.82 ∙ 103
G0 mol m-3 1.00 ∙ 10-6
kg min-1 4.00
kp m3 min-1 plt-1 2.12 ∙ 10-15
R0 mol m-3 min-1 1.65 ∙ 10-5
P0 mol plt-1 3.58 ∙ 10-18
S m2 1.00 ∙ 102
Qtot m3 min-1 5.60 ∙ 10-3
t1/2 min 7.20 ∙ 103
w m 1.00 ∙ 10-6
zg 0.27
zng 0.73
α min-1 0
β plt m-3 min-1 0
θh 0.25
θp 0.08
θv 0.50
ρ m-1 9.70 ∙ 104
σ 0.56
τ min 1.04 ∙ 104
Ωb m3 5.40 ∙ 10-3
Ωg m3 1.03 ∙ 10-3

Updated steady-state P = 2.40 ∙ 10-18 mol/platelet

Original steady-state P = 2.40 ∙ 10-18 mol/platelet

Last updated: June 5, 2008