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Janušonis Lab
Department of Psychological and Brain Sciences
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Platelet Hyperserotonemia of Autism
The current state of the theory of the platelet hyperserotonemia of autism is presented in Janušonis (2008) [Open Access]. This paper supersedes our two previous theoretical papers (Janušonis (2005) Theor. Biol. Med. Model. 2: 27 and Janušonis (2005) Med. Hypotheses 64: 742-750).
The numerical values of the parameters are being constantly updated as more data become available. The table below lists:
- all parameters and their original values used in Janušonis (2008),
- the most recent updates on the parameters' numerical values and the sources of the updates,
- other relevant sources not cited in Janušonis (2008).
Any corrections or comments will be greatly appreciated.
| PARAMETER | UNITS | ORIGINAL VALUE | UPDATED VALUE | SOURCE OF UPDATE | OTHER SOURCES |
| 5-HT MW | g mol-1 | 176 | |||
| D | m2 min-1 | 6.00 ∙ 10-8 | |||
| db | m3 min-1 | 6.00 | |||
| dg | min-1 | 5.82 ∙ 103 | |||
| G0 | mol m-3 | 1.00 ∙ 10-6 | |||
| kg | min-1 | 4.00 | 1.19 | Gill et al. (2008) Am. J. Physiol. Gastrointest. Liver Phys. 294: G254-G262. | |
| kp | m3 min-1 plt-1 | 2.12 ∙ 10-15 | |||
| R0 | mol m-3 min-1 | 1.65 ∙ 10-5 | < 10-4 based on Gronstad et al. (1988) J. Surg. Res. 44: 146-151. | ||
| P0 | mol plt-1 | 3.58 ∙ 10-18 | |||
| S | m2 | 1.00 ∙ 102 | 3.00 | Based on Humer et al. (1996) J. Appl. Physiol. 81: 895-904. | |
| Qtot | m3 min-1 | 5.60 ∙ 10-3 | |||
| t1/2 | min | 7.20 ∙ 103 | |||
| w | m | 1.00 ∙ 10-6 | |||
| zg | 0.27 | ||||
| zng | 0.73 | ||||
| α | min-1 | 0 | |||
| β | plt m-3 min-1 | 0 | |||
| θh | 0.25 | ||||
| θp | 0.08 | ||||
| θv | 0.50 | ||||
| ρ | m-1 | 9.70 ∙ 104 | |||
| σ | 0.56 | ||||
| τ | min | 1.04 ∙ 104 | |||
| Ωb | m3 | 5.40 ∙ 10-3 | |||
| Ωg | m3 | 1.03 ∙ 10-3 |
Updated steady-state P = 2.43 ∙ 10-18 mol/platelet
Original steady-state P = 2.40 ∙ 10-18 mol/platelet
Last updated: April 23, 2011